USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

USC-OGP 2-DE database  Search by                Maps             Select Remote Interfaces [All Interfaces] SWISS-2DPAGE World-2DPAGE Portal World-2DPAGE Repository Exclude local DBs has only effect if a remote interface is selected

Searching in 'USC-OGP 2-DE database' for entry matching: SODM_HUMAN USC-OGP 2-DE database:  SODM_HUMAN SODM_HUMAN General information about the entry View entry in simple text format Entry name SODM_HUMAN Primary accession number P04179 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Superoxide dismutase [Mn], mitochondrial; EC=1.15.1.1; Flags: Precursor;. Gene name Name=SOD2 Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein PLATELET_6-11 {PLATELET 6-11} Homo sapiens (Human)   map experimental info   PLATELET_6-11 MAP LOCATIONS: SPOT OGP-1030: pI=6.69; Mw=22601 SPOT OGP-1032: pI=6.98; Mw=22469 SPOT OGP-1033: pI=6.91; Mw=22404 UVEAL_MELANOMA_3-10 {UVEAL MELANOMA 3-10} Homo sapiens (Human)   map experimental info   UVEAL_MELANOMA_3-10 MAP LOCATIONS: SPOT OGP-1304: pI=6.93; Mw=22446 Cross-references UniProtKB/Swiss-Prot P04179; SODM_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name SODM_HUMAN Primary accession number P04179 Secondary accession number(s) B2R7R1 B3KUK2 B4DL20 B4E3K9 E1P5A9 P78434 Q16792 Q5TCM1 Q96EE6 Q9P2Z3 Sequence was last modified on  April 1, 1990 (version 2) Annotations were last modified on  March 15, 2017 (version 208) Name and origin of the protein Description RecName: Full=Superoxide dismutase [Mn], mitochondrial; EC=1.15.1.1; Flags: Precursor; Gene name Name=SOD2 Encoded on Name=SOD2 Keywords 3D-structure; Acetylation; Alternative splicing; Complete proteome; Direct protein sequencing; Manganese; Metal-binding; Mitochondrion; Nitration; Oxidoreductase; Polymorphism; Reference proteome; Transit peptide. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL X59445; CAA42066.1; -; mRNA EMBL Y00472; CAA68533.1; -; mRNA EMBL Y00985; CAA68791.1; -; mRNA EMBL X07834; CAA30687.1; -; mRNA EMBL M36693; AAA36622.1; -; mRNA EMBL X15132; CAA33228.1; -; mRNA EMBL X14322; CAA32502.1; -; mRNA EMBL S77127; AAD14248.1; ALT_SEQ; Genomic_DNA EMBL BT006967; AAP35613.1; -; mRNA EMBL AY267901; AAP03428.1; -; Genomic_DNA EMBL AK097395; BAG53464.1; -; mRNA EMBL AK296809; BAG59382.1; -; mRNA EMBL AK304766; BAG65521.1; -; mRNA EMBL AK313082; BAG35908.1; -; mRNA EMBL AL135914; CAI21845.1; -; Genomic_DNA EMBL CH471051; EAW47630.1; -; Genomic_DNA EMBL CH471051; EAW47631.1; -; Genomic_DNA EMBL BC012423; AAH12423.1; -; mRNA CCDS CCDS34564.1; -. [P04179-2]; . CCDS CCDS5265.1; -. [P04179-1]; . CCDS CCDS83141.1; -. [P04179-4]; . CCDS CCDS83143.1; -. [P04179-3]; . PIR S13162; DSHUN; . RefSeq NP_000627.2; NM_000636.3; . RefSeq NP_001019636.1; NM_001024465.2; . RefSeq NP_001019637.1; NM_001024466.2; . RefSeq NP_001309743.1; NM_001322814.1; . RefSeq NP_001309744.1; NM_001322815.1; . RefSeq NP_001309746.1; NM_001322817.1. [P04179-4]; . RefSeq NP_001309748.1; NM_001322819.1. [P04179-4]; . RefSeq NP_001309749.1; NM_001322820.1. [P04179-4]; . UniGene Hs.487046; -; . PDB 1AP5; X-ray; 2.20 A; A/B=25-222 PDB 1AP6; X-ray; 1.90 A; A/B=25-222 PDB 1EM1; X-ray; 2.13 A; A/B=25-222 PDB 1JA8; X-ray; 2.12 A; A/B=25-222 PDB 1LUV; X-ray; 1.85 A; A/B=25-222 PDB 1LUW; X-ray; 2.30 A; A/B=25-222 PDB 1MSD; X-ray; 3.20 A; A/B=25-222 PDB 1N0J; X-ray; 2.20 A; A/B=25-222 PDB 1N0N; X-ray; 1.82 A; A/B=25-222 PDB 1PL4; X-ray; 1.47 A; A/B/C/D=25-222 PDB 1PM9; X-ray; 1.70 A; A/B=25-222 PDB 1QNM; X-ray; 2.30 A; A/B=25-222 PDB 1SZX; X-ray; 1.95 A; A/B=25-222 PDB 1VAR; X-ray; 2.50 A; A/B=25-222 PDB 1XDC; X-ray; 1.85 A; A/B=25-222 PDB 1XIL; X-ray; 1.53 A; A/B=25-222 PDB 1ZSP; X-ray; 1.90 A; A/B=25-222 PDB 1ZTE; X-ray; 1.85 A; A/B/C/D=25-222 PDB 1ZUQ; X-ray; 2.00 A; A/B=25-222 PDB 2ADP; X-ray; 2.40 A; A=25-222 PDB 2ADQ; X-ray; 2.40 A; B=25-222 PDB 2GDS; X-ray; 2.30 A; A/B/C/D=25-222 PDB 2P4K; X-ray; 1.48 A; A/B/C/D=25-222 PDB 2QKA; X-ray; 2.20 A; A/C=25-220 PDB 2QKC; X-ray; 2.30 A; A/C=25-220 PDB 3C3S; X-ray; 2.50 A; A/B=25-222 PDB 3C3T; X-ray; 2.20 A; A/B=25-222 PDBsum 1AP5; -; . PDBsum 1AP6; -; . PDBsum 1EM1; -; . PDBsum 1JA8; -; . PDBsum 1LUV; -; . PDBsum 1LUW; -; . PDBsum 1MSD; -; . PDBsum 1N0J; -; . PDBsum 1N0N; -; . PDBsum 1PL4; -; . PDBsum 1PM9; -; . PDBsum 1QNM; -; . PDBsum 1SZX; -; . PDBsum 1VAR; -; . PDBsum 1XDC; -; . PDBsum 1XIL; -; . PDBsum 1ZSP; -; . PDBsum 1ZTE; -; . PDBsum 1ZUQ; -; . PDBsum 2ADP; -; . PDBsum 2ADQ; -; . PDBsum 2GDS; -; . PDBsum 2P4K; -; . PDBsum 2QKA; -; . PDBsum 2QKC; -; . PDBsum 3C3S; -; . PDBsum 3C3T; -; . ProteinModelPortal P04179; -; . SMR P04179; -; . BioGrid 112531; 38; . IntAct P04179; 20; . MINT MINT-5002369; -; . STRING 9606.ENSP00000356022; -; . DrugBank DB04436; 3-Fluorotyrosine; . DrugBank DB03297; Benzylsulfinic Acid; . Allergome 784; Hom s MnSOD; . iPTMnet P04179; -; . PhosphoSitePlus P04179; -; . SwissPalm P04179; -; . BioMuta SOD2; -; . DMDM 134665; -; . DOSAC-COBS-2DPAGE P04179; -; . OGP P04179; -; . SWISS-2DPAGE P04179; -; . UCD-2DPAGE P04179; -; . EPD P04179; -; . MaxQB P04179; -; . PaxDb P04179; -; . PeptideAtlas P04179; -; . PRIDE P04179; -; . TopDownProteomics P04179-1; -. [P04179-1]; . TopDownProteomics P04179-2; -. [P04179-2]; . DNASU 6648; -; . Ensembl ENST00000546087; ENSP00000442920; ENSG00000112096. [P04179-4]; . GeneID 6648; -; . KEGG hsa:6648; -; . UCSC uc003qsf.6; human. [P04179-1]; . CTD 6648; -; . DisGeNET 6648; -; . GeneCards SOD2; -; . HGNC HGNC:11180; SOD2; . HPA CAB002013; -; . HPA HPA001814; -; . MalaCards SOD2; -; . MIM 147460; gene; . MIM 612634; phenotype; . neXtProt NX_P04179; -; . OpenTargets ENSG00000112096; -; . PharmGKB PA36017; -; . eggNOG KOG0876; Eukaryota; . eggNOG COG0605; LUCA; . GeneTree ENSGT00390000011877; -; . HOGENOM HOG000013583; -; . HOVERGEN HBG004451; -; . InParanoid P04179; -; . KO K04564; -; . PhylomeDB P04179; -; . TreeFam TF105132; -; . BioCyc MetaCyc:HS03515-MONOMER; -; . BRENDA 1.15.1.1; 2681; . Reactome R-HSA-3299685; Detoxification of Reactive Oxygen Species; . Reactome R-HSA-8862803; Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models; . SIGNOR P04179; -; . ChiTaRS SOD2; human; . EvolutionaryTrace P04179; -; . GeneWiki SOD2; -; . GenomeRNAi 6648; -; . PRO PR:P04179; -; . Proteomes UP000005640; Chromosome 6; . Bgee ENSG00000112096; -; . CleanEx HS_SOD2; -; . ExpressionAtlas P04179; baseline and differential; . Genevisible P04179; HS; . GO GO:0070062; C:extracellular exosome; IDA:UniProtKB; . GO GO:0005759; C:mitochondrial matrix; TAS:BHF-UCL; . GO GO:0005739; C:mitochondrion; IDA:BHF-UCL; . GO GO:0042802; F:identical protein binding; IPI:IntAct; . GO GO:0030145; F:manganese ion binding; IDA:UniProtKB; . GO GO:0004784; F:superoxide dismutase activity; IDA:UniProtKB; . GO GO:0001315; P:age-dependent response to reactive oxygen species; IMP:UniProtKB; . GO GO:0008285; P:negative regulation of cell proliferation; IMP:BHF-UCL; . GO GO:0043524; P:negative regulation of neuron apoptotic process; IGI:BHF-UCL; . GO GO:1902176; P:negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway; IMP:BHF-UCL; . GO GO:0032364; P:oxygen homeostasis; IMP:BHF-UCL; . GO GO:0051289; P:protein homotetramerization; IPI:UniProtKB; . GO GO:0008217; P:regulation of blood pressure; ISS:BHF-UCL; . GO GO:0006357; P:regulation of transcription from RNA polymerase II promoter; IMP:UniProtKB; . GO GO:0001836; P:release of cytochrome c from mitochondria; ISS:BHF-UCL; . GO GO:0019430; P:removal of superoxide radicals; IMP:BHF-UCL; . GO GO:0000302; P:response to reactive oxygen species; TAS:Reactome; . GO GO:0000303; P:response to superoxide; IMP:BHF-UCL; . GO GO:0006801; P:superoxide metabolic process; IDA:UniProtKB; . GO GO:0003069; P:vasodilation by acetylcholine involved in regulation of systemic arterial blood pressure; ISS:BHF-UCL; . InterPro IPR001189; Mn/Fe_SOD; . InterPro IPR019833; Mn/Fe_SOD_BS; . InterPro IPR019832; Mn/Fe_SOD_C; . InterPro IPR019831; Mn/Fe_SOD_N; . Pfam PF02777; Sod_Fe_C; 1; . Pfam PF00081; Sod_Fe_N; 1; . PIRSF PIRSF000349; SODismutase; 1; . PRINTS PR01703; MNSODISMTASE; . SUPFAM SSF46609; SSF46609; 1; . SUPFAM SSF54719; SSF54719; 1; . PROSITE PS00088; SOD_MN; 1; .

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